Conference paper

Bispecific DuoBody antibody targeting 4-1BB on cancer cells and PD-L1 on T cells for immunotherapy in non-small cell lung cancer (NSCLC)

Mohammad Aarish Khan, Gaurav Sharma

2025 IEEE Integrated STEM Education Conference (ISEC) • March 15, 2025

DOI: 10.1109/ISEC64801.2025.11147433

Abstract

This computational immunotherapy study evaluates a bispecific DuoBody antibody designed to engage 4-1BB on cancer cells and PD-L1 on T cells in non-small cell lung cancer, using structural modeling and interaction analysis tools such as AlphaFold, GROMACS, HDock, PLIP, and Prodigy.

Keywords

cancer immunotherapybispecific antibodiescomputational biologyNSCLC

Citation

Khan, M. A., and Sharma, G. “Bispecific DuoBody Antibody Targeting 4-1BB on Cancer Cells and PD-L1 on T Cells for Immunotherapy in Non-Small Cell Lung Cancer (NSCLC).” 2025 IEEE Integrated STEM Education Conference (ISEC), Princeton, NJ, USA, 2025, pp. 1–5. doi: 10.1109/ISEC64801.2025.11147433