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Research

Research programs and scholarly work

Bispecific Antibody Design for Cancer Immunotherapy
Published

Bispecific Antibody Design for Cancer Immunotherapy

Computational design of a bispecific DuoBody antibody targeting 4-1BB and PD-L1 for non-small cell lung cancer, published at IEEE ISEC 2025.

cancer immunotherapybispecific antibodiescomputational biology
Outcome
Docking and molecular dynamics confirmed an optimal bispecific antibody design for 4-1BB and PD-L1. The selected design showed high predicted affinity and stability, supporting it as a promising NSCLC-targeting candidate. Published at IEEE ISEC 2025 and recognized with the Outstanding Poster Presentation Award (ACS NERD 2025) and the Medal of High Honors (Terra Science Fair).
Method
  1. 1.Protein selection
  2. 2.Structure modeling
  3. 3.Binding-site identification
  4. 4.Molecular docking
  5. 5.Interaction analysis
  6. 6.Molecular dynamics
Tools
AlphaFoldGROMACSHDockPLIPProdigyBiopythonStreamlit
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Ongoing

Neurological Condition Genetics Research

FLAMES and FUMA-based analysis of genome-wide association data to investigate the genetic basis of neurological conditions.

neurological conditionsschizophreniageneticscomputational biology
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Ongoing

Nushoor Water Purification Research

Low-cost, UV-based water purification system fine-tuned for disenfranchised communities, designed around resource constraints.

water purificationpublic healthsystems design
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