Conference paper
Bispecific DuoBody antibody targeting 4-1BB on cancer cells and PD-L1 on T cells for immunotherapy in non-small cell lung cancer (NSCLC)
Mohammad Aarish Khan, Gaurav Sharma
2025 IEEE Integrated STEM Education Conference (ISEC) • March 15, 2025
This computational immunotherapy study evaluates a bispecific DuoBody antibody designed to engage 4-1BB on cancer cells and PD-L1 on T cells in non-small cell lung cancer, using structural modeling and interaction analysis tools such as AlphaFold, GROMACS, HDock, PLIP, and Prodigy.